Various Drugs That May Interact With CBD Oil

If you are undergoing any medication, then you should always talk to your doctor before consuming CBD oil. This is because CBD tends to interact with certain types of medicine. Read on to find more on the type of drugs with which CBD interacts in the body.

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How Does CBD Oil Impact The Body?

When a person consumes CBD oil, then it travels to the liver and interacts with the endocannabinoid system. This is the system that controls several mental and physical functions of the body. Though safe is generally safe, sometimes it leads to a few side-effects. In some people, it is seen to inhibit the cytochrome P450 enzyme system.

This system has over fifty enzymes. It is present in the liver. It metabolizes toxic compounds, which include more than 60% percent of drugs that a person consumes. The system has processes and expels toxins from the body.

Cannabidiol can inhibit the Cytochrome P-450 System and reduce its effectiveness in metabolizing specific drugs. This, ultimately results in an increase in processing times and a higher amount of drugs in the system at a certain point. The overdose of the drug results in undesired side effects in the body.

What Drugs Can Interact with Cannabidiol?

Any drug that CYP450 enzymes metabolize has the ability to interact with Cannabidiol. Some of them include:

  • Steroids
  • Calcium channel blockers
  • Antihistamines
  • HMG CoA reductase inhibitors
  • Prokinetics
  • HIV antivirals
  • Benzodiazepines
  • Antiarrythmics
  • Antibiotics
  • Oral hypoglycemic agents
  • Immune modulators
  • Anesthetics
  • Antipsychotics
  • Anti-epileptics
  • Beta-blockers
  • PPIs
  • Antidepressants
  • NSAIDs
  • Angiotension II blockers
  • Sulfonylureas

It is always necessary to check with the doctor before you consume any of the above medications. This is to ensure the safety of consumption of Cannabidiol along with the medication.

Your doctor may consider adjusting the CBD dosage on the type, time, and number of medications you consume. This will ensure that both products are safe to consume.

What Drugs Interact With CBD Oil?

Here are the two substances that you should avoid when consuming CBD oil.

  • Drugs that have alcohol should not be mixed with CBD oil to avoid probable side effects.
  • CBD oil is also increasingly used with caffeine. However, due to similarity in their nature, the high amounts of substances can lead to sedation and drowsiness in the body.

As CBD oil can modify the crucial liver enzymes in the body, it is best to perform your research, discuss with a physician, and find out the best way to consume CBD oil for your situation.


Some people metabolize cannabidiol differently due to anomalies in the cytochrome P45O enzyme system. Based on when you consume medications, you may experience a decrease or increase in CBD concentrations in the blood.

If you suspect that your body isn’t capable to metabolize CBD oil as expected, then ask the doctor to test the cytochrome P450 enzyme system before adjusting the CBD dosage.

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